Musk Ketone
Aroma Chemical Base Note CAS 81-14-1
Sweet, dry and powdery musk with a soft, slightly floral character and great tenacity. It adds a clean powderiness and lasting base to white floral accords.
Odor profile
| Note | Base Note |
| Descriptor 1 | Musk-like |
| Descriptor 2 | Sweet |
| Descriptor 3 | Powdery |
| Odor Impact1 | 35 |
| Impact Level | Medium |
| Tenacity1 | 600 h |
| Tenacity2 | 400 h |
1 Source: PerfumersWorld
2 Source: The Good Scents Company
Both tenacity figures are blotter life. The two labs use different evaluation protocols, so the numbers are not directly comparable — read them as two independent readings, not as a contradiction.
Identification
| CAS Number | 81-14-1 |
| INCI Name | 4'-tert-butyl-2',6'-dimethyl-3',5'-dinitroacetophenone |
| Category | Aroma Chemical |
| Formula | C14H18N2O5 |
| Mol. Weight | 294.30 |
| IUPAC Name | 1-(4-tert-butyl-2,6-dimethyl-3,5-dinitrophenyl)ethanone |
| InChIKey | WXCMHFPAUCOJIG-UHFFFAOYSA-N |
Synonyms
2,6-Dinitro-3,5-dimethyl-4-acetyl-t.butylbenzene, 2,6-Dimethyl-4-tert.butyl-3,5-dinitro-acetophenone, Musk ketone Musk ketone, Ketonmoskus, 2,6-Dinitro-3,5-dimethyl-4-acetyl tertiary butylbenzene, 2,6-Dimethyl-3,5-dinitro-4-tertiary butylacetophenone, 4-tertiary Butyl-3,5-dinitro-2,6-dimethyl acetophenone, acetophenone, 4-tert-butyl-2,6-dimethyl-3,5-dinitro-, 1-acetyl-4-(tert-butyl)-2,6-dimethyl-3,5-dinitrobenzene, 1-(4-tert-butyl-2,6-dimethyl-3,5-dinitro-phenyl)-ethanone, 4-tert-butyl-2,6-dimethyl-3,5-dinitroacetophenone, 1-(4-tert-butyl-2,6-dimethyl-3,5-dinitrophenyl)ethanon, 1-(4-tert-butyl-2,6-dimethyl-3,5-dinitrophenyl)ethanone, 4-tert-butyl-2,6-dimethyl-3,3-dinitroacetophenone, 4-tert-butyl-3,5-dinitro-2,6-dimethyl acetophenone, 4-tert-butyl-3,5-dinitro-2,6-dimethylacetophenone, 1-(4-(tert-butyl)-2,6-dimethyl-3,5-dinitrophenyl)ethanone, 1-[4-(tert-butyl)-2,6-dimethyl-3,5-dinitrophenyl]ethan-1-one, 1-(4-(1,1-dimethyl ethyl)-2,6-dimethyl-3,5-dinitrophenyl) ethanone, 2,6-dimethyl-3,5-dinitro-4-tert-butylacetophenone, 1-[2,6-dimethyl-4-(2-methyl-2-propanyl)-3,5-dinitrophenyl]ethanone, 1-(4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl) ethanone, 1-(4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl)ethanone, 1-[4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]ethanone, 3,5-dinitro-2,6-dimethyl-4-tert-butyl acetophenone, 2,6-dinitro-3,5-dimethyl-4-acetyl-tert-butyl benzene, ethanone, 1-(4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl)-, ethanone, 1-[4- (1,1-dimethylethyl)-2,6-dimethyl-3, 5-dinitrophenyl]-, ethanone, 1-[4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]-, ketone moschus, musk ketone extra, muskketone
Physical and chemical data
| Boiling Point | 395.00 °C |
| Melting Point | 136.5 °C |
| Flash Point | 168.0 °C |
| Density | 0.73 |
| Vapor Pressure | 3.00X10-7 mm Hg at 25 °C |
| LogP | 3.7 |
| Solubility | In water, 0.46 mg/L at 25 °C |
| Appearance | Musk ketone is a light yellow crystalline solid. Insoluble in water. (NTP, 1992) |
Regulatory status
IFRA maximum concentrations
| Category | Use | Limit in the finished product |
|---|---|---|
| Category 1 | Lip products, toys | 0.0033 % |
| Category 2 | Deodorants, antiperspirants | 0.14 % |
| Category 3 | Eye products | 0.19 % |
| Category 4 | Fine fragrance | 2.6 % |
| Category 5A | Body lotion | 0.65 % |
| Category 5B | Face cream | 0.11 % |
| Category 5C | Hand cream | 0.13 % |
| Category 5D | Baby creams, oils | 0.036 % |
| Category 6 | Oral care, mouthwash | 0.0033 % |
| Category 7A | Rinse-off hair products | 0.090 % |
| Category 7B | Leave-on hair products | 0.090 % |
| Category 8 | Intimate and baby wipes | 0.036 % |
| Category 9 | Soap, shampoo, rinse-off | 0.75 % |
| Category 10A | Household care, hand contact | 0.12 % |
| Category 10B | Aerosol air fresheners | 0.85 % |
| Category 11A | Intended skin contact | 0.036 % |
| Category 11B | Minimal skin contact | 0.036 % |
| Category 12 | No skin contact, candles | 17 % |
| IFRA Amendment | 52 |
| Restriction Type | Restriction / Specification |
| Critical Effect | Dermal Sensitization And Systemic Toxicity |
| Specification | Musk xylene (CAS number 81-15-2), which has been prohibited for use in fragrance compounds for environmental reasons (vPvB), can be present in Musk ketone as an impurity. Musk ketone should only be used if it contains less than 0.1% of Musk xylene. |
All figures on this page are guide values collected from public reference works and supplier declarations. They differ between batches, origins and qualities. The data sheet of your own supplier is always the authoritative document for the material you actually use.